Figured I'd get some of you who haven't gotten a chance to try it out for yourselves yet up to speed on what to expect in H2H.
1. O-line logic seems messed up. EA must have tried to patch it and messed it up. It's a lot easier for user rushes to succeed. My opponent was able to user rush from the SubLB position and consistently reach the backfield. Tried it myself on defense and it worked for me too. This serves as a heads up that you will most definitely need a quarterback with a fast release. Also, make quick reads.
2. This seems to balance out the O-line logic a bit: It's easier for wide receivers to catch the ball. Now that it is literally impossible for players to run all KO abilities on their CBs, it's easier for your pass catchers to get the ball.
3. Defense is more difficult. My own personal Nickel 24 Man Blitz scheme still works, but it requires a lot more user activity. I would recommend getting good at guessing plays. The meta offensive schemes are still prevalent, but it's pretty easy to see if your opponent is running Bench or PA Seams.
4. Deep Route KO or Deep Out Zone KO are necessary. You can take away most short and medium routes with your user, but you don't want to give up the deep shot to a now agg-catch friendly meta. Even then it's difficult to get stops, but usually you only need one to win a game if you're good on offense.