Not sure if many people at this point in the game are interested in common strategies, but this item is good. It may say CB on the cover, but in fact it boosts all your safeties too
even those who are not in your "Defense" tab, but in "Specialists" only - like Kam at SUBLB:
As you can see, he still gets those +3 ZCV, +2 MCV and +2 PRC from Hybrid
And of course he gets all the physical boosts from 50/50 Chiefs also. But that's not surprising at all. In case someone didn't know, players with crossed out chems don't count toward team's total (i.e. Kam doesn't add +1 to my Chiefs count), but they still receive all the boosts their chems imply.